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多发性肌炎(polymyositis,PM)时引起肌损伤的确切机理仍未明,但有证据提示细胞介导和体液免疫受累。患者肌组织中有淋巴细胞炎性浸润及其周围血淋巴细胞对胎儿肌肉有细胞毒性,均提示患者肌组织破坏归咎于细胞介导免疫。此外,PM 患者有特异性自身抗体,但后者在该病发病机理中的作用仍不清楚。作者首次报告3例 PM 患者的肌损伤与血清单克隆抗体有关。3例患者,男1、女2例,年龄分别为69、64和54岁。渐进性肌软弱无力历时分别为3个月、4年和12年,临床和肌电图、肌活检均符合典型肌炎。血沉
The exact mechanism of muscle damage caused by polymyositis (PM) remains unclear, but evidence suggests that cell-mediated and humoral immunity are involved. Patients with inflammatory infiltration of lymphocytes in the muscle tissue and cytotoxicity of peripheral blood lymphocytes to fetal muscle both suggest that the destruction of muscle tissue in patients is attributed to cell-mediated immunity. In addition, PM patients have specific autoantibodies, but the role of the latter in the pathogenesis of the disease remains unclear. The authors first report 3 PM patients with muscle damage and serum monoclonal antibody. Three patients, male 1 and female 2, aged 69, 64 and 54 respectively. Progressive muscle weakness lasted respectively 3 months, 4 years and 12 years, clinical and electromyography, muscle biopsy are in line with the typical myositis. ESR