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心肌细胞凋亡是人的心脏功能呈衰退的主要原因,心脏功能的丧失是健康人自然死亡的主要原因[1]。细胞凋亡在心脏的生理、病理发展过程中起重要作用,与许多心血管疾病的发生发展密切相关,被认为是心脏由代偿性变化向生理性、病理性变化发展的细胞学基础。胰岛素样生长因子Ⅰ(insulin like growth factorⅠ,IGF-Ⅰ)是一类多功能细胞增殖调控因子。在细胞的分化、增殖、个体的生长发育中具有重要的促进作用。IGF-Ⅰ对心肌细胞的保护作用已在动物体内外得到证实[2-4]。Abbas等[5]研究发现,在动脉硬化和冠心病患者的体内血清IGF-Ⅰ浓度较健康对照组偏低,并证
Cardiomyocyte apoptosis is the main reason for the decline of cardiac function in human. The loss of cardiac function is the main reason of natural death in healthy people [1]. Apoptosis plays an important role in the physiological and pathological development of the heart and is closely related to the occurrence and development of many cardiovascular diseases. It is considered as the cytology basis for the development of physiological and pathological changes from compensatory changes of the heart. Insulin-like growth factor Ⅰ (IGF-Ⅰ) is a kind of multifunctional cell proliferation regulators. In the cell differentiation, proliferation, individual growth and development has an important role in promoting. The protective effects of IGF-I on cardiomyocytes have been demonstrated both in vivo and in vitro [2-4]. Abbas et al [5] found that in patients with arteriosclerosis and coronary heart disease serum IGF-Ⅰ concentration is lower than the healthy control group, and evidence