目的探讨越鞠丸改良配方治疗乳腺癌术后化疗致胃肠道反应的临床疗效。方法选取泸州医学附属中医医院乳腺外科2015年4月—2016年7月收治的乳腺癌术后化疗致胃肠道反应患者100例,随机分为对照组和研究组,各50例。对照组患者给予麻仁丸治疗,研究组患者给予越鞠丸改良方治疗,两组患者均持续治疗2个月。比较两组患者临床疗效及治疗前、治疗后2个月血清指标[5-羟色胺(5-HT)、血清P物质(SP)、神经激肽1受体(NK1)],观察两组患者不良反应发生情况。结果研究组患者总有效率高于对照组(P<0.05)。治疗前,两组患者5-HT、SP和NK1水平比较,差异无统计学意义(P>0.05);治疗后2个月,研究组患者5-HT、SP水平低于对照组,NK1水平高于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用越鞠丸改良方治疗乳腺癌术后化疗致胃肠道反应的临床疗效确切,可有效缓解患者胃肠道反应,改善胃肠功能,且安全可靠。 Objective To investigate the clinical efficacy of Yueju Pill modified formula in the treatment of gastrointestinal reactions induced by postoperative chemotherapy of breast cancer. Methods 100 cases of gastrointestinal reactions induced by postoperative chemotherapy of breast cancer who were treated in Department of Breast Surgery, Luzhou Medical Affiliated Hospital of Traditional Chinese Medicine from April 2015 to July 2016 were randomly divided into control group and study group, 50 cases each. Patients in the control group were treated with Maren pill. Patients in the study group were treated with Yueju Pills modified prescription. Both groups were treated for 2 months. The clinical efficacy of the two groups of patients was compared before and after treatment with serum markers of 5-HT, SP and NK1 2 months after treatment. Reaction occurred. Results The total effective rate of study group was higher than that of control group (P <0.05). Before treatment, there was no significant difference in the levels of 5-HT, SP and NK1 between the two groups (P> 0.05). At 2 months after treatment, the levels of 5-HT and SP in the study group were lower than those in the control group In the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion The treatment of Yueju pill improved postoperative chemotherapy induced gastrointestinal tract response to the clinical curative effect is exact, can effectively relieve gastrointestinal reactions in patients with gastrointestinal function to improve, and safe and reliable.