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目的:探讨轮状病毒(RV)肠炎患儿的在腹泻、呕吐、发热及脱水程度等临床表现与肠外多脏器损伤的相关性。方法:选取2009年1月~2012年6月在我院儿科住院治疗的轮状病毒肠炎患儿193例,留取其大便、尿液及血液,以便进行大便常规、肠道细菌培养、RV抗原检查、尿常规、血常规以及生化指标检测,所有患儿行胸部X线、心电图等常规检查,并根据诊断标准判断其肠外脏器损伤情况。结果:193例RV肠炎患儿中有呼吸系统损伤120例,占62.17%,心肌损伤82例,占42.49%,肝脏损伤63例,占32.64%,肾脏损伤22例,占11.40%,神经系统损伤15例,占7.77%;呕吐持续≥3d与呼吸系统损伤、肾脏损伤及神经系统损伤有相关性,差异有统计学意义(P<0.05);腹泻≥10次/d与呼吸系统损伤有相关性,差异有统计学意义(P<0.05);发热持续≥3d及中重度脱水与心肌损伤、肝脏损伤、肾脏损伤及神经损伤有相关性,差异有统计学意义(P<0.05)。结论:RV肠炎患儿临床表现严重程度与肠外脏器损伤存在一定的相关性。
Objective: To investigate the correlation between the clinical manifestations of diarrhea, vomiting, fever and dehydration and other multiple organ injury in children with rotavirus (RV) enteritis. Methods: From January 2009 to June 2012, 193 children with rotavirus enteritis treated in pediatric department of our hospital were selected for stool, urine and blood for stool routine, intestinal bacterial culture, RV antigen All the children underwent routine examination such as chest X-ray and electrocardiogram, and according to the diagnostic criteria, to judge the damage of extraintestinal organ. Results: Among the 193 patients with RV enteritis, there were 120 cases of respiratory system injury, accounting for 62.17%, 82 cases of myocardial injury, accounting for 42.49%, 63 cases of liver injury accounting for 32.64%, 22 cases of kidney injury accounting for 11.40%, and nervous system injury 15 cases, accounting for 7.77%; vomiting continued for 3 days and respiratory system injury, kidney injury and nervous system injury were related, the difference was statistically significant (P <0.05); diarrhea ≥ 10 times / d and respiratory system injury , The difference was statistically significant (P <0.05); fever sustained ≥ 3d and moderate to severe dehydration and myocardial injury, liver injury, kidney damage and nerve injury were related, the difference was statistically significant (P <0.05). Conclusion: There is a correlation between the severity of clinical manifestations and the damage of parenteral organs in children with.