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目的 探讨系统性红斑狼疮(SLE)患者中γ-干扰素(IFN-γ)表达的自然情况。方法 用逆转录-多聚酶链反应(RT-PCR)法检测了15例SLE患者和10例正常人外周血单个核细胞(PBMC)中IFNγ mRNA表达的水平。结果 与正常人相比,活动期SLE患者PBMC中IFNγ mRNA表达水平降低(P<0.01)。结果 SLE患者中IFNγ的表达下调。
Objective To investigate the natural expression of interferon-γ (IFN-γ) in patients with systemic lupus erythematosus (SLE). Methods The levels of IFNγ mRNA in peripheral blood mononuclear cells (PBMCs) of 15 SLE patients and 10 normal controls were detected by reverse transcription polymerase chain reaction (RT-PCR). Results Compared with normal controls, the expression of IFNγ mRNA in PBMC of active SLE patients decreased (P <0.01). Results The expression of IFNγ was down-regulated in SLE patients.