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目的:了解本院临床分离的不动杆菌属分布特点及对常用抗菌药物的耐药情况。方法:收集2007年1月~2008年12月临床送检各类标本中分离的212株不动杆菌,对其药敏试验结果进行统计分析。结果:不动杆菌临床分离株主要来源于痰标本(83.0%)。药敏结果显示,不动杆菌对亚胺培南和美罗培南耐药率分别为8.5%和5.6%,对头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、阿米卡星和四环素的耐药率分别为32.6%、34.0%、39.6%和43.3%,多粘菌素B较敏感,对其它抗菌药物的耐药率均大于50%。多重耐药率为66.0%(140/212)。结论:不动杆菌是引起医院呼吸道感染的重要病原菌之一,对现有抗菌药物耐药严重,碳青霉烯类及多粘菌素B是控制不动杆菌感染的有效药物。
OBJECTIVE: To understand the distribution characteristics of Acinetobacter isolated from our hospital and its resistance to commonly used antibiotics. Methods: A total of 212 strains of Acinetobacter isolated from clinical specimens from January 2007 to December 2008 were collected and their susceptibility test results were statistically analyzed. Results: The main clinical isolates of Acinetobacter were sputum samples (83.0%). The susceptibility results showed that the rates of resistance of Acinetobacter to imipenem and meropenem were 8.5% and 5.6%, respectively. Cefoperazone / sulbactam, piperacillin / tazobactam, amikacin and tetracycline Were 32.6%, 34.0%, 39.6% and 43.3%, respectively. Polymyxin B was more sensitive than other antibacterials, and the resistance rate to other antibiotics was more than 50%. The multi-drug resistance rate was 66.0% (140/212). Conclusion: Acinetobacter is one of the important pathogenic bacteria causing respiratory tract infections in hospitals. It is resistant to the existing antibacterial drugs. Carbapenems and polymyxin B are effective drugs for controlling Acinetobacter infection.