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目的:探讨妊娠肝内胆汁淤积症(ICP)与胎儿生长受限(FGR)的关系。方法:回顾性分析20例ICP患者与对照组妊娠结局、新生儿体重、FCR发生率的比较及ICP新生儿体重与胆汁酸、肝功能的关系。结果:ICP组早产、羊水粪染、Apgar评分<7分(1 min)的发生率与对照组比较差异有统计学意义,P<0.01。ICP组新生儿平均体重为(3 233.9±1 475.5)g,FGR的发生率为5.0%,与正常组相比差异无统计学意义。多元线性回归分析,ICP组新生儿体重与胆汁酸、肝功能无明显线性关系。结论:ICP与胎儿生长受限之间无明显相关性。
Objective: To investigate the relationship between intrahepatic cholestasis of pregnancy (ICP) and fetal growth restriction (FGR). Methods: A retrospective analysis of 20 cases of ICP patients and control group, pregnancy outcomes, neonatal weight, FCR incidence and ICP neonatal body weight and bile acid, liver function. Results: The incidence of preterm birth, meconium stained amniotic fluid, Apgar score <7 (1 min) in ICP group was significantly lower than that in control group (P <0.01). The average neonatal weight of ICP group was (233.3 ± 1475.5) g and the incidence of FGR was 5.0%, which showed no significant difference compared with normal group. Multivariate linear regression analysis, ICP group of newborns weight and bile acid, liver function no significant linear relationship. Conclusion: There is no significant correlation between ICP and fetal growth restriction.