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在胃癌术后复发者中,腹膜播种占多数,对此没有切实有效的抑制手段,为此作者在胃癌术后施行腹腔内温水灌流(intarperitoneal hyperthermic perfusion,IPHP),并取得了良好的效果。在行IPHP时,将抗癌剂丝裂霉素(MMC)加入灌流液中使用,因而称温热化学疗法,这样能提高抗癌效果。另外,为了在同一条件下,增强抗癌效果,可使用温热增感剂——2-硝基咪唑的诱导体misonidazole(MIS)。本文为了确认这些药剂的抗癌效果和安全性,对于该药在IPHP实施中的体内动态也加以研讨。一、对象和方法实施IPHP对象为进展期胃癌10例,男5例,女5例,平均年龄51.6±10.8岁。
In the recurrence of gastric cancer, peritoneal seeding accounts for the majority, there is no effective suppression means for this reason, the authors performed intraperitoneal hyperthermic perfusion (IPHP) after gastric cancer surgery, and achieved good results. In the case of IPHP, the use of the anti-cancer agent mitomycin (MMC) in the perfusate is called thermochemotherapy, which enhances the anti-cancer effect. In addition, in order to enhance the anti-cancer effect under the same conditions, a warming sensitizer, 2-nitroimidazole inducer misonidazole (MIS), may be used. In order to confirm the anticancer effect and safety of these agents, the in vivo dynamics of this drug in the implementation of IPHP were also studied. I. Objects and Methods IPHP targets were performed in 10 patients with advanced gastric cancer, 5 males and 5 females, with an average age of 51.6±10.8 years.