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目的观察腹膜透析和血液透析对尿毒症患者血清肌钙蛋白T/I及钙磷代谢的影响效果。方法选择尿毒症患者88例,根据患者的自身情况进行分组,其中进行腹膜透析治疗组(观察组)56例,进行血液透析治疗组(对照组)32例,观察2组患者透析前后血清肌钙蛋白T/I水平变化以及钙磷含量变化情况。结果透析后,观察组CTnT/I、hs-CTnT/I水平均低于对照组,高血磷的发生率则高于对照组,差异有统计学意义(P<0.05)。治疗前,观察组患者的甲状旁腺激素水平低于对照组,差异具有统计学意义(P<0.05),治疗后6个月,观察组患者的血钙、血磷、钙磷乘积以及甲状旁腺激素水平均低于对照组,差异有统计学意义(P<0.05)。结论腹膜透析不仅可降低血清肌钙蛋白含量,降低心血管事件发生可能,而且可更好地控制尿毒症患者的钙磷代谢,保护残肾功能,具有临床推广价值。
Objective To observe the effects of peritoneal dialysis and hemodialysis on serum troponin T / I and calcium and phosphorus metabolism in uremic patients. Methods Eighty-eight patients with uremia were selected and divided into groups according to the patient’s condition. Among them, 56 cases were treated with peritoneal dialysis (observation group), 32 cases were treated with hemodialysis (control group) Protein T / I level changes and changes in calcium and phosphorus content. Results After dialysis, the levels of CTnT / I and hs-CTnT / I in the observation group were lower than those in the control group, and the incidence of hyperphosphatemia was higher than that in the control group (P <0.05). Before treatment, the level of parathyroid hormone in the observation group was lower than that in the control group (P <0.05). After 6 months of treatment, the levels of serum calcium, phosphorus, calcium and phosphorus in the observation group and parathyroid The levels of gonadal hormones were lower than the control group, the difference was statistically significant (P <0.05). Conclusion Peritoneal dialysis not only can reduce serum troponin content, reduce the possibility of cardiovascular events, but also better control of calcium and phosphorus metabolism in patients with uremia, the protection of residual renal function, with clinical value.