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目的:探讨声门上型喉癌颈部转移淋巴结分型与对侧转移及预后的关系。方法:对248例术后随访资料完整的声门上型喉癌患者进行回顾性分析,术后均行颈廓清标本的病理连续切片,颈廓清标本采用透明淋巴结摘出连续切片法。分析不同临床病理因素与对侧转移的关系及生存分析。结果:115例标本发现有颈淋巴结转移,转移率为46.4%;其中单发型转移39例,多发型转移34例,融合型转移42例。单发型转移对侧转移率为5.1%,多发型为44.1%,融合型61.9%,对侧转移并且与肿瘤跨中线侵犯和临床N分级相关。单发转移患者3、5年生存率分别为79.5%和74.4%;多发转移患者3、5年生存率分别为61.8%和41.2%;融合转移患者3、5年生存率分别为61.9%和35.7%。结论:多发型和融合型转移患者应行对侧颈廓清术,颈淋巴结转移类型是判断患者预后的重要指标。
Objective: To investigate the relationship between cervical lymph node metastasis and contralateral metastasis and prognosis of supraglottic laryngeal carcinoma. Methods: A retrospective analysis was performed on 248 patients with supraglottic laryngeal cancer who underwent follow-up. All the patients underwent serial pathological sectioning of the neck with clear specimens and serial sections of clear-cut cervical lymph nodes were obtained. Analysis of different clinical and pathological factors and contralateral metastasis and survival analysis. Results: 115 cases of cervical lymph node metastasis was found, the transfer rate was 46.4%; of which 39 cases of single-type transfer, multiple transfer 34 cases, fusion transfer in 42 cases. The rate of metastatic metastases was 5.1% in single-hair type, 44.1% in multiple hair type, and 61.9% in fusion type. It was metastasized to the contralateral side and was associated with tumor metastasis and clinical N-grade. The 3- and 5-year survival rates of patients with single metastasis were 79.5% and 74.4%, respectively. The 3- and 5-year survival rates of patients with multiple metastases were 61.8% and 41.2%, respectively. The 3- and 5-year survival rates of patients with metastatic disease were 61.9% and 35.7% %. Conclusions: The patients with multiple and fusion metastases should undergo contralateral neck dissection. The type of cervical lymph node metastasis is an important index to judge the prognosis of patients.