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目的:评价阿莫西林颗粒(再林)对小儿感染性疾病的疗效及安全性。方法:采用随机对照开放试验,试验组1 983例,口服阿莫西林颗粒40-80mg·kg-1,tid;对照组693例,口服头孢拉定干混悬剂6.25-12.5mg·kg-1,tid,疗程7-14d。结果:试验组痊愈率和总有效率分别为69.49％和91.88％,优于对照组的35.93%和60.46％(P<0.05);细菌清除率试验组96.67％,对照组83.33％,2组比较差异有极显著性(P<0.01);不良反应发生率试验组1.46％,对照组4.91％,差异有极显著性(P<0.01)。结论:阿莫西林颗粒治疗儿科感染性疾病疗效较好,在服药前需详细询问青霉素及其他药物过敏史,首剂应在医护人员密切观察下服药。
Objective: To evaluate the efficacy and safety of amoxicillin granules (reforestation) in children with infectious diseases. METHODS: A randomized controlled open-label trial was conducted in 1 983 patients in the experimental group with 40-80 mg · kg -1 tamoxifen administered orally, 693 patients in the control group and 6.25-12.5 mg · kg -1 of cefradine dry suspension. , Treatment 7-14d. Results: The cure rate and total effective rate of the experimental group were 69.49% and 91.88%, respectively, which were higher than 35.93% and 60.46% (P <0.05) of the control group. The bacterial clearance rate was 96.67% in the experimental group and 83.33% in the control group. The difference was significant (P <0.01). The incidence of adverse reactions was 1.46% in the test group and 4.91% in the control group, the difference was significant (P <0.01). Conclusions: Amoxicillin Granules are effective in treating pediatric infectious diseases. Before taking the drug, it is necessary to ask about the history of penicillin and other drug allergy. The first dose should be taken closely by the medical staff.