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目的动态监测产褥感染产妇血清细胞因子及抗氧化能力指标的变化,并探讨其临床价值。方法选择2013年7月至2014年12月在湖北孝昌县第一人民医院妇产科住院治疗的67例产褥感染患者为观察组,其中外阴阴道及宫颈炎22例,子宫内膜炎及输卵管炎26例,盆腔腹膜炎19例。选择同期住院分娩未发生产褥感染的65例产妇作为对照组。分别在产后1、3、5 d检测各组产妇血清白细胞介素-6(interleukin-6,IL-6)、血清C-反应蛋白(C-reaction protein,CRP)、抗凝血酶原Ⅲ(antithrombinⅢ,AT-Ⅲ)、降钙素原(procalcitionin,PCT)等细胞因子水平及总抗氧化能力(total antioxidant capacity,TAC)、超氧化歧化酶(superoxide dismutase,SOD)、脂质过氧化产物丙二醛(malonaldehyde,MDA)、髓过氧化化物酶(myeloperoxidase,MPO)等抗氧化能力指标。结果观察组不同时间点血清IL-6、CRP、PCT、MDA、MPO水平均明显高于对照组(P<0.05);AT-Ⅲ、TAC、SOD明显低于对照组(P<0.05)。随着产褥感染产妇的病情加重,血清IL-6、CRP、PCT、MDA、MPO水平逐渐升高(P<0.05),而血清AT-Ⅲ、TAC、SOD逐渐降低(P<0.05)。结论动态监测血清细胞因子和抗氧化能力指标有助于判断产褥感染病情的严重程度,具有一定的临床价值。
Objective To dynamically monitor changes of serum cytokines and antioxidant capacity in puerperal infection males and explore its clinical value. Methods From July 2013 to December 2014, 67 cases of puerperal infection in obstetrics and gynecology department of First People’s Hospital of Xiaochang County, Hubei Province were selected as the observation group, including 22 cases of vulvovaginitis and cervicitis, endometritis and fallopian tube 26 cases of inflammation, 19 cases of pelvic peritonitis. Select the same period of hospital delivery did not occur in 65 cases of puerperal infection as a control group. The levels of serum interleukin-6 (IL-6), serum C-reaction protein (CRP), antithrombin Ⅲ (TAC), superoxide dismutase (SOD), lipid peroxidation product C Malonaldehyde (MDA), myeloperoxidase (MPO) and other antioxidant capacity indicators. Results The levels of IL-6, CRP, PCT, MDA and MPO in the observation group were significantly higher than those in the control group at different time points (P <0.05). The AT-Ⅲ, TAC and SOD were significantly lower in the observation group than those in the control group (P <0.05). Serum levels of IL-6, CRP, PCT, MDA and MPO increased gradually (P <0.05), while serum AT-Ⅲ, TAC and SOD decreased gradually (P <0.05). Conclusions The dynamic monitoring of serum cytokines and antioxidant capacity indicators can help determine the severity of puerperal infection and have certain clinical value.