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本研究探讨头孢克肟对健康SD大鼠甲状腺功能的影响。采用SPF级雄性SD大鼠40只,随机分为正常组、对照组、头孢克肟高、低剂量组各10只。除正常组外,分别给予生理盐水、头孢克肟18 mg/kg、36 mg/kg灌胃,每日1次,连续4周。给药结束1周后,取血及甲状腺,ELISA法测定血清FT3、FT4、TSH、rT3,HE染色、光镜观察甲状腺组织病理变化。ELISA法结果显示,与正常组和对照组比较,头孢克肟高、低剂量组血清FT3、FT4、rT3水平均降低,差异有统计学意义(p<0.05),正常组与对照组之间对比无统计学意义(p>0.05)。HE染色结果显示,头孢克肟高、低剂量组甲状腺滤泡大小不均匀,滤泡明显萎缩,滤泡间可见大量淋巴细胞。本研究结果提示,头孢克肟可导致健康SD大鼠甲状腺功能减退。
This study was to investigate the effect of cefixime on thyroid function in healthy SD rats. Forty Sprague-Dawley male Sprague-Dawley rats were randomly divided into normal group, control group and cefixime high and low dose groups. In addition to the normal group, were given saline, cefixime 18 mg / kg, 36 mg / kg gavage once daily for 4 weeks. One week after the administration, blood and thyroid were taken out. Serum FT3, FT4, TSH, rT3 and HE were detected by ELISA. Pathological changes of thyroid tissue were observed by light microscope. The results of ELISA showed that the levels of serum FT3, FT4 and rT3 in high and low doses of cefixime were significantly lower than those in normal group and control group (p <0.05), and the difference between normal group and control group No statistical significance (p> 0.05). The results of HE staining showed that the size of thyroid follicles in high and low doses of cefixime was not uniform, the follicles obviously shrank, and a large number of lymphocytes were observed in the follicles. Our results suggest that cefixime can cause hypothyroidism in healthy SD rats.