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目的探讨原发性高血压(EH)患者血清血管紧张素Ⅰ(AⅠ)、血管紧张素Ⅱ(AⅡ)、心钠素(ANF)和醛固酮(ALD)水平及经苯那普利干预治疗后的变化及其临床意义。方法放射免疫法测定310例EH组和80例非高血压组血清AⅠ、AⅡ、ANF和ALD水平,对其中80例EH患者给予苯那普利干预治疗,测定其治疗前后上述血管活性肽的变化。结果EH患者血清AⅠ、AⅡ和ALD水平显著高于对照组(t=7.841,t=5.038,t=13.80;P均<0.01),ANF则否(P>0.05);Ⅰ、Ⅱ、Ⅲ期组间四者血清水平的方差检验无显著性差异(P均>0.05)。EH组中,80例经(61.7±22.6)d的苯那普利干预治疗后血清AⅡ水平显著下降、ALD水平却显著升高(P均<0.01)。结论EH患者血清AⅠ、AⅡ和ALD水平显著升高,苯那普利使AⅡ水平显著下降、ALD水平却显著升高。
Objective To investigate the changes of serum levels of AⅠ, AⅡ, ANF and ALD in patients with essential hypertension (EH) Change and its clinical significance. Methods The levels of AⅠ, AⅡ, ANF and ALD in 310 cases of EH and 80 cases of non-hypertension were measured by radioimmunoassay, and 80 cases of EH were treated with benazepril. The changes of the above vasoactive peptides before and after treatment . Results The levels of serum AⅠ, AⅡ and ALD in EH patients were significantly higher than those in the control group (t = 7.841, t = 5.038, t = 13.80; P <0.01) There was no significant difference between the four groups in serum test of variance (P> 0.05). In the EH group, serum AⅡ level was significantly decreased and ALD level was significantly increased after 80 (61.7 ± 22.6) days of benazepril treatment (all P <0.01). Conclusions The levels of AⅠ, AⅡ and ALD in serum of EH patients were significantly increased. Benazepril significantly decreased A Ⅱ level and ALD level.