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目的了解胃粘膜肠上皮化生及不典型增生在胃肠道疾病中的发生率，及其与胃癌的关系．方法病例来自１９８６０１／１９９５１２中山医院进行内镜检查的患者．２６５７８例，男１７０９２例（６４３％），女９４８０例（３５７％），检出胃癌５３８例（２０％）；胃溃疡２５６９例（９７％）；十二指肠溃疡６１２７例（２３１％）；复合溃疡８４１例（３２％）．比较各组肠上皮化生及不典型增生的检出率．结果肠上皮化生检出率为３３９％，随年龄增加而增加，在胃癌组［４９８％，ＯＲ＝１７８（９５％ＣＩ１４９～２３１）］，胃溃疡组［５１６％，ＯＲ＝２１２（９５％ＣＩ１９５～２３１）］明显高于慢性胃炎组（３３４％）．总的不典型增生检出率为（５１％），随年龄增加而增加．胃癌组［１６２％，ＯＲ＝４８７（９５％ＣＩ３７８～６２６）］，胃溃疡组［１３２％，ＯＲ＝３８２（９５％ＣＩ３３１～４４１）］，复合溃疡组［１１７％，ＯＲ＝３３５（９５％ＣＩ２６５～４２２）］明显高于慢性胃炎组（３８％）．结论肠上皮化生及不典型增生的发生随年龄增加而增加．在胃癌及胃溃疡患者中，其发生率明显高于慢性胃炎患者．肠上?
Objective To understand the incidence of gastric intestinal metaplasia and atypical hyperplasia in gastrointestinal diseases, and its relationship with gastric cancer. Methods Cases from 1986-01/1995-12 Zhongshan Hospital for endoscopy patients. In 26578 cases, 17092 cases (64. 3%) were males and 9480 (35.7%) were females. 538 cases (2.0%) of gastric cancer were detected; 2569 cases (9.7%) of stomach ulcers; duodenum; 6127 cases of ulcers (23.1%); 841 cases of composite ulcers (3. 2%). The detection rate of intestinal metaplasia and atypical hyperplasia in each group was compared. Results The detection rate of intestinal metaplasia was 33.9%, which increased with age. In the gastric cancer group [49.8%, OR=1.78 (95% CI149-2.31)], gastric ulcer group. [516%, OR=212(95% CI195～231)] was significantly higher than that of chronic gastritis group (334%). The overall detection rate of atypical hyperplasia (51%) increased with age. Gastric cancer group [162%, OR=487 (95% CI378-626)], gastric ulcer group [132%, OR=382 (95% CI331～441) )], composite ulcer group [11 7%, OR = 3 35 (95% CI2 65 4 22)] was significantly higher than the group with chronic gastritis (3 8%). Conclusion The occurrence of intestinal metaplasia and atypical hyperplasia increases with age. In gastric cancer and gastric ulcer patients, the incidence was significantly higher than that of patients with chronic gastritis. Intestines?