目的探讨广西壮族系统性红斑狼疮(SLE)与HLA-DRB1基因的相关性。方法用聚合酶链反应-序列特异性引物(PCR-SSP)方法,对52例SLE壮族患者和70例壮族健康人的HLA-DRB1基因进行研究。结果SLE患者HLA-DRB1*1401及DRB1*16两个等位基因的频率低于正常对照组(RR=0.28,χ2=5.00,P=0.02及RR=0.39,χ2=3.95,P=0.05),患者组和对照组均未检出HLA-DRB1*08、DRB1*11和DRB1*13等位基因。结论提示HLA-DRB1*1401及DRB1*16等位基因可能是广西壮族人SLE的保护基因,未发现易感基因。 Objective To investigate the relationship between Guangxi SLE and HLA-DRB1 gene. Methods The HLA-DRB1 gene of 52 SLE patients and 70 healthy people from Zhuang nationality were studied by polymerase chain reaction-sequence-specific primers (PCR-SSP). Results The frequencies of HLA-DRB1 * 1401 and DRB1 * 16 alleles in patients with SLE were significantly lower than those in controls (RR = 0.28, χ2 = 5.00, P = 0.02 and RR = 0.39, χ2 = 3.95, No HLA-DRB1 * 08, DRB1 * 11 and DRB1 * 13 alleles were detected in the patient group and the control group. The results suggest that HLA-DRB1 * 1401 and DRB1 * 16 alleles may be protective genes of Guangxi SLE and no susceptible genes were found.