糖尿病是严重危害人类健康和生命的世界性流行病,大血管病变及其终点事件是导致2型糖尿病患者死亡的最重要原因,然而,动脉钙化和粥样硬化是糖尿病大血管病变的两个主要表现形式,其中血管钙化即血管结构的骨化是与骨发育相似的主动性、高度可调控性的生物学过程,受参与调节糖代谢和骨代谢过程的各种要素交叉作用和影响。其中胰高血糖素样肽-1 Diabetes mellitus is a worldwide epidemic that seriously affects human health and life, and macrovascular disease and its end point are the most important causes of death in patients with type 2 diabetes. However, arterial calcification and atherosclerosis are the two major causes of diabetic macroangiopathy Manifestations in which vascular calcification, the ossification of vascular structures, is an active, highly regulatable biological process similar to bone development that is interplayed and influenced by various elements involved in the regulation of glucose metabolism and bone metabolism. Among them glucagon-like peptide-1