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淋巴道转移是肿瘤转移的重要途径,也是判断预后的重要依据。如何预防和抑制肿瘤转移一直是肿瘤研究的重点和热点。大量研究表明,恶性肿瘤和瘤周组织中存在新生的淋巴管,能够促进肿瘤的转移扩散,而且其密度与淋巴结转移密切相关。近年来研究发现,Neuropilins表达可能与肿瘤淋巴管新生和淋巴结转移密切相关,以Neuropilins为新型治疗靶点对恶性肿瘤淋巴管生成和转移进行靶向治疗也取得初步的研究成果。以上为揭示恶性肿瘤淋巴道转移的机制和开发淋巴管靶向治疗提供了重要的研究途径。
Lymphatic metastasis is an important way of tumor metastasis, but also to determine the prognosis of an important basis. How to prevent and inhibit tumor metastasis has always been the focus of cancer research and hot spots. Numerous studies have shown that malignant tumors and peritumor tissue exist in the new lymphatic vessels, can promote tumor metastasis and proliferation, and its density and lymph node metastasis are closely related. In recent years, studies have found that Neuropilins expression may be closely related to tumor lymphangiogenesis and lymph node metastasis. Neuropilins as a novel therapeutic target for lymphangiogenesis and metastasis of malignant tumors also achieved preliminary research results. The above provides an important research approach for revealing the mechanism of lymphatic metastasis of malignant tumors and developing lymphatic targeted therapy.