部分性21-羟化酶缺乏所致的迟发型先天性肾上腺皮质增生(LOCAH)病人在临床及生化方面均无皮质醇水平低下的表现。为检测LOCAH病人HPA轴(下丘脑—垂体—肾上腺轴)几种激素的水平与变化,作者曾研究12名病人。这些病人诊断的确立是基于静脉注射250μg的ACTH(1-24)后60分钟血浆17羟孕酮(17-OHP)浓度超过1500ng/dL这一标准。其中女10例,男2例,年 Partial partial 21-hydroxylase deficiency in patients with delayed type congenital adrenal hyperplasia (LOCAH) in clinical and biochemical aspects of the performance of low cortisol levels. To test the level and changes of several hormones in the HPA axis (hypothalamic-pituitary-adrenal axis) of patients with LOCAH, the authors studied 12 patients. The diagnosis of these patients was based on the criteria that the plasma 17-OHP concentration exceeded 1500 ng / dL 60 minutes after intravenous injection of 250 μg of ACTH (1-24). Among them, 10 cases were female and 2 were male,