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目的 研究肥胖伴黑棘皮病儿童胰岛素分泌功能的改变 ,探讨其临床意义。方法 对35例肥胖伴黑色棘皮病患儿、38例单纯肥胖患儿及 39例正常儿童进行胰岛 β细胞功能指标的测定。结果 肥胖伴黑色棘皮病组空腹胰岛素、C肽、胰岛素原、真胰岛素、胰岛素原与胰岛素、C肽比值、胰岛素抵抗指数和胰岛 β细胞分泌指数 (中位数及范围 )分别为 18 5 (5 0～ 6 0 5 )pmol/L、3 9(1 3～14 0 ) μg/L、2 8 84 (9 9～ 6 4 2 )pmol/L、32 96 (6 2～ 6 6 0 )pmol/L、1 2 (0 4～ 8 9)、6 9(2 5～ 36 6 )、5 0(0 8～ 14 1)和 30 3 3(5 2 2～ 116 3 8) ,均显著高于单纯肥胖组和正常组 (P <0 0 0 1)。结论 肥胖伴黑色棘皮病已经存在严重的胰岛 β细胞分泌亢进和胰岛素抵抗 ,是儿童患 2型糖尿病的高危 信号
Objective To study the changes of insulin secretion in obese children with acanthosis nigricans (AM) and to explore its clinical significance. Methods 35 cases of obese patients with black acanthosis, 38 cases of simple obesity children and 39 normal children were measured for β-cell function. Results The fasting insulin, C peptide, proinsulin, true insulin, proinsulin, insulin, C peptide ratio, insulin resistance index and pancreatic β cell secretion index (median and range) in obesity with black acanthosis were 18 5 (5 (P <0.05), the average daily dose of POM was (P <0.05) L 1 2 (0 4 ~ 8 9), 6 9 (2 5 ~ 36 6), 5 0 (0 8 ~ 14 1) and 30 3 3 (5 2 2 ~ 1 16 3 8) Obesity group and normal group (P <0.01). Conclusion Obesity associated with acanthosis nigricans has been exacerbated pancreatic β-cell hypersecretion and insulin resistance, is a high risk of type 2 diabetes in children