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目的 肿瘤微血管计数和碱性成纤维细胞生长因子 (bFGF)是反映肿瘤微血管形成的重要指标。本文研究它们与乳腺癌预后的关系。方法 收集我院近年收治的乳腺癌 3 2例 ,并随访。采用免疫组化LSAB法 ,检测vWf和bFGF在乳腺癌组织中的表达。采用Weidner法进行微血管计数。通过影响生存率的单因素和多因素分析 ,确定影响预后的因素。结果 平均肿瘤微血管计数为 3 6 42。T3+T4与T1+T2 相比 ,肿瘤微血管计数明显增高。肿瘤微血管计数增高对预后有明显影响。bFGF阳性表达率为 68 75 % ,阳性组中肿瘤微血管计数明显增高。bFGF的表达对预后无明显影响。结论 肿瘤微血管计数可作为乳腺癌预后的指标 ,而bFGF在肿瘤形成和肿瘤生长有重要作用但不能作为临床预后的指标。
Objective Tumor microvessel count and basic fibroblast growth factor (bFGF) are important indicators of tumor microvessel formation. This article studies their relationship with the prognosis of breast cancer. Methods Collecting 32 cases of breast cancer admitted to our hospital in recent years and followed up. Immunohistochemical LSAB method was used to detect the expression of vWf and bFGF in breast cancer tissues. Weidner method for microvascular count. Factors influencing the prognosis were determined by univariate and multivariate analysis of survival rates. Results The mean tumor microvessel count was 36.42. Tumor microvessel counts were significantly higher in T3 + T4 compared to T1 + T2. Increased tumor microvessel counts have a significant effect on prognosis. The positive rate of bFGF was 68 75%. The positive rate of tumor microvessel in the positive group was significantly higher than that in the positive group. bFGF expression had no significant effect on prognosis. Conclusions Tumor microvessel counts can be used as an indicator of breast cancer prognosis, while bFGF plays an important role in tumor formation and tumor growth but can not be used as an indicator of clinical prognosis.