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为研究凝血因子IX基因剔除小鼠的生长繁育和血液学指标等生物学特性,对种群中38窝母鼠所生仔鼠进行生长发育指标的测定,测其5、10、15、21、30、40、50、60日龄的体重、体长和尾长;测定交配种鼠的繁殖性能及发病时间和临床症状;部分小鼠的血液生理、生化值。结果表明,5、21日龄平均体重分别为3.70 g,3.44 g和11.12 g,10.35 g;初配至生产平均30.24d,产仔数5.39只,平均离乳率81.09％。小鼠发病时间30～90日龄不等,有出血症状;凝血因子IX基因剔除小鼠的血液成分指标与正常小鼠基本一致。
In order to study the biological characteristics of growth and reproduction and hematological indexes of coagulation factor IX knockout mice, the indexes of growth and development of offspring of 38 litters in the population were determined. , Body weight, body length and tail length at 40, 50 and 60 days of age. The reproductive performance, onset time and clinical symptoms of the mating mice were determined. The blood physiological and biochemical values of some mice were determined. The results showed that the average body weights at 5 and 21 days were 3.70 g, 3.44 g and 11.12 g, 10.35 g respectively. The average primary birth rate was 30.24 days and the number of litter size was 5.39 with the average rate of 81.09%. Mice onset time ranging from 30 to 90 days, with bleeding symptoms; coagulation factor IX gene knockout mice blood composition indicators and normal mice are basically the same.