论文部分内容阅读
目的探讨脑心通胶囊联合阿托伐他汀治疗脑梗死颈动脉粥样硬化的临床疗效。方法选取2013年6月—2015年6月北京市仁和医院收治的脑梗死颈动脉粥样硬化患者90例,随机分为观察组与对照组,各45例。观察组给予脑心通胶囊联合阿托伐他汀治疗,对照组给予阿司匹林肠溶片联合阿托伐他汀治疗。比较两组患者治疗前后血脂指标[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、颈动脉内膜-中层厚度(IMT)和斑块面积变化情况,治疗前以及治疗后不同时间同型半胱氨酸(Hcy)水平。结果治疗前两组患者TG、TC、LDL-C、HDL-C水平比较,差异无统计学意义(P>0.05);治疗后观察组TG、TC、LDL-C水平低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者IMT及斑块面积比较,差异无统计学意义(P>0.05);治疗后观察组IMT及斑块面积小于对照组,差异有统计学意义(P<0.05)。治疗前两组患者Hcy水平比较,差异无统计学意义(P>0.05);治疗后1、3、6个月Hcy水平均低于对照组,差异有统计学意义(P<0.05)。结论脑心通胶囊联合阿托伐他汀治疗脑梗死颈动脉粥样硬化的疗效确切,能够有效缓解患者临床症状,改善体征指标。
Objective To investigate the clinical effects of Naoxintong capsule combined with atorvastatin on carotid atherosclerosis in patients with cerebral infarction. Methods Ninety patients with carotid atherosclerosis in cerebral infarction who were admitted to Beijing Renhe Hospital from June 2013 to June 2015 were randomly divided into observation group and control group with 45 cases in each group. The observation group was given Naoxintong capsule combined with atorvastatin, while the control group was given aspirin enteric-coated tablets combined with atorvastatin. The serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) Middle thickness (IMT) and plaque area changes, before treatment and at different times after treatment of homocysteine (Hcy) levels. Results There was no significant difference in TG, TC, LDL-C and HDL-C levels between the two groups before treatment (P> 0.05). The levels of TG, TC and LDL-C in the observation group were lower than those in the control group C levels higher than the control group, the difference was statistically significant (P <0.05). There was no significant difference in IMT and plaque area between the two groups before treatment (P> 0.05). After treatment, the IMT and plaque area in the observation group were smaller than those in the control group (P <0.05). There was no significant difference in Hcy levels between the two groups before treatment (P> 0.05). The Hcy levels at 1, 3 and 6 months after treatment were lower than those in the control group (P <0.05). Conclusion Naoxintong capsules combined with atorvastatin treatment of cerebral infarction carotid atherosclerosis exact effect, can effectively alleviate the clinical symptoms and improve physical indicators.