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目的探讨产科DIC应用抑肽酶治疗后对各项凝血指标的影响和继续出血量、输血量的影响。方法25例产科DIC的患者随机分为抑肽酶组(A组):抑肽酶100 K IU加入250 ml生理盐水中静脉滴注;常规治疗组(B组):输入同量的生理盐水,其他抢救措施两组相同。观察两组患者继续失血量、新鲜冰冻血浆、异体红细胞输注量以及红细胞压积(HCT)、血小板计数(PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆纤维蛋白原含量(FIB)的变化。结果抑肽酶组平均继续失血量、异体红细胞和新鲜冰冻血浆的需要量较常规治疗组减少,PT、APTT、FIB、PLT恢复至正常的时间较对照组明显缩短(P<0.01)。结论抑肽酶能明显减少产科DIC患者平均继续失血量和异体红细胞、血浆的需要量,加快凝血系统各项指标恢复正常。
Objective To investigate the influence of obstetric DIC aprotinin on various coagulation indexes and the effects of continuous bleeding and blood transfusion. Methods 25 cases of obstetric DIC were randomly divided into aprotinin group (A group): aprotinin 100 K IU added 250 ml saline intravenous drip; conventional treatment group (B): the same amount of saline, Other rescue measures are the same for both groups. The amount of blood loss, fresh frozen plasma, allogeneic red blood cell transfusion, hematocrit (HCT), platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT) Changes in fibrinogen content (FIB). Results In aprotinin group, blood loss was maintained on average. The required amount of allogeneic red blood cells and fresh frozen plasma were decreased compared with those in the conventional treatment group. The PT, APTT, FIB and PLT returned to normal levels were significantly shorter than those in the control group (P <0.01). Conclusions Aprotinin can significantly reduce the average blood loss and the number of allogeneic red blood cells and plasma in patients with obstetric DIC, and accelerate the normalization of various indexes in the coagulation system.