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产生于肺组织中的前列腺素E_2(简称PGE_2)具有潜在抗过敏作用。为了解吸入PGE_2对过敏性哮喘的作用,本研究采用双盲对照法给8例哮喘病人分别吸入PGE_2和安慰剂以进行观察。 方法 8例非吸烟(7男)特异性哮喘病人接受了本项研究.受试前至少6h停用β_2受体兴奋剂.48h停用皮质类固醇.受试者既往均有吸入过敏原后发生迟发性支气管哮喘反应的病史(吸入过敏原后4至7hFEV下降>15％)。试验分两步进行.在第一步试验中,患者在分别吸入安慰剂或PGE_2后吸入生理盐水5
Prostaglandin E_2 (PGE_2) produced in lung tissue has potential anti-allergic effect. In order to understand the effect of PGE 2 inhalation on allergic asthma, we used eight double-blind controls to treat 8 asthmatic patients with inhaled PGE 2 and placebo for observation. Methods Eight non-smoking (7 male) patients with specific asthma were enrolled in this study. Β 2 -receptor agonists were discontinued at least 6 hours prior to the test and corticosteroids were discontinued 48 hours after the subjects had previously inhaled allergens A history of bronchial asthma reactions (> 4% reduction in FEV 4 to 7 h after allergen inhalation). The trial was conducted in two steps: In the first trial, the patient inhaled saline 5 after inhalation of either placebo or PGE 2