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目的:探讨老年原发性高血压病患者动态血压节律与肾功能损害的相关性。方法:选择老年原发性高血压患者262例,根据动态血压监测结果分为健康对照组、杓性组、非杓性组。检测各组微量白蛋白(MAU)、尿肌酐(Cr)及二者比值(UACR),用简单线性相关分析其与动态血压各参数之间的相关性。结果:杓性组和非杓性组MAU和UACR明显高于对照组,而非杓性组高于杓性组(均P<0.05)。MAU与UACR均与24h平均收缩压、24h平均舒张压、夜间平均收缩压、夜间平均收缩压呈正相关。结论:MAU和UACR是老年高血压患者肾功能损害预测指标,MAU和UACR与24h动态血压呈明显相关性,其中UACR与24h动态血压的相关性较显著。
Objective: To investigate the correlation between ambulatory blood pressure rhythm and renal dysfunction in elderly patients with essential hypertension. Methods: 262 elderly patients with essential hypertension were selected and divided into healthy control group, dipper group and non-dipper group according to the results of ambulatory blood pressure monitoring. Microalbuminuria (MAU), urinary creatinine (Cr), and ratio of both (UACR) were detected in each group. The correlations between them and parameters of ambulatory blood pressure were analyzed by simple linear correlation. Results: The MAU and UACR in dipper group and non-dipper group were significantly higher than those in control group, but not in dipper group (P <0.05). MAU and UACR were 24h mean systolic blood pressure, 24h mean diastolic blood pressure, nighttime average systolic blood pressure, nighttime average systolic blood pressure was positively correlated. CONCLUSION: MAU and UACR are predictors of renal dysfunction in elderly patients with hypertension. MAU and UACR are significantly correlated with 24-hour ambulatory blood pressure. The correlation between ambulatory blood pressure and UACR is significant.