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[目的]探讨七氟醚吸入麻醉对肺癌根治术患者血清E-选择素(E-selectin)、基质金属蛋白酶(MMP)及免疫功能恢复的影响.[方法]本院拟接受肺癌根治手术的86例患者,随机分为七氟醚组(A组)和异氟醚组(B组),每组43例,监测并对比两组患者围手术期麻醉诱导前(T0)、手术开始后1 h(T1)、2 h(T2)、术毕1 h(T3)时刻E-selectin、MMP-2、MMP-9、白细胞介素-6(IL-6)、肿瘤坏死因子-a(TNF-a)、可溶性白细胞介素2受体(sIL-2R)的水平.[结果]A组患者的血清E-selectin、MMP-2、MMP-9和TNF-a水平在T1、T2、T3时刻均低于B组(P＜0.05);A组患者的血清IL-6水平在T2、T3时刻均低于B组(P＜0.05),两组患者在各个时间点的sIL-2R水平比较差异无显著性(P＞0.05).[结论]七氟醚吸入麻醉能有效抑制E-selectin、MMP-2、MMP-9水平的升高,有利于患者免疫功能的恢复.“,”[Objective] To investigate the effect of inhalation anesthesia on E-selectin,matrix metalloproteinase (MMP) and immune function recovery in patients with lung cancer.[Methods]Eighty-six cases of radical resection of lung cancer were selected in our hospital and were randomly divided into sevoflurane group (n =43) and isoflurane group (n =43).The levels of E-selectin,MMP-2,MMP-9,interleukin-6(IL-6),tumor necrosis factor-a and soluble interleukin-2 receptor (sIL-2R) were monitored and compared at the time of anesthesia induction (T0),1h after operation start (T1),2h(T2) and 1h after operation (T3).[Results]The serum levels of E-selectin,MMP-2,MMP-9 and TNF-a in the group A were lower than those in group B at time of T1 、T2 、T3 (P ＜0.05).The level of serum IL-6 in the group A was lower than that in group B at time of T1,T2 and T3 (P ＜0.05).There was no significant difference in the level of sIL-2R between the two groups at each time point (P ＞0.05).[Conclusion]Sevoflurane inhalation anesthesia can effectively inhibit the increase of E-selectin,MMP-2 and MMP-9,which is beneficial to the recovery of the immune function of the patients.