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目的 :探讨不同剂量阿托伐他汀对老年脑梗死患者临床预后的影响。方法 :选取2012年2月-2013年10月在我院住院治疗的老年脑梗死患者114例,按随机数字表法分为大剂量组(n=64)和低剂量组(n=50),大剂量组和低剂量组患者在常规治疗的基础上分别加用阿托伐他汀40 mg/d和10 mg/d口服治疗。结果 :治疗后第3个月,两组患者NIHSS评分均明显降低,Barthel指数明显升高(P<0.05),但组间差异无显著性(P>0.05);治疗后第12个月,两组患者稳定性斑块积分均明显升高,不稳定性斑块积分均明显降低,且组间差异具有统计学意义(P<0.05);大剂量组患者治疗后1年内复发率为9.38%,低剂量组患者为16.00%,差异具有统计学意义(P<0.05)。结论 :大剂量阿托伐他汀可有效改善动脉粥样硬化斑块的稳定性,减少脑梗死的复发。
Objective: To investigate the effect of different doses of atorvastatin on clinical prognosis of elderly patients with cerebral infarction. Methods: A total of 114 elderly patients with cerebral infarction who were hospitalized in our hospital from February 2012 to October 2013 were divided into high dose group (n = 64) and low dose group (n = 50) according to random number table. Patients in high-dose group and low-dose group were treated with atorvastatin 40 mg / d and 10 mg / d orally on the basis of routine treatment. Results: At the third month after treatment, the NIHSS scores of both groups were significantly decreased, Barthel index was significantly increased (P <0.05), but there was no significant difference between the two groups (P> 0.05). At the 12th month after treatment, The stable plaque scores of patients in group A and B were significantly increased, and the scores of unstable plaques were significantly lower (P <0.05). The recurrence rate of high-dose group was 9.38% within 1 year after treatment, The low dose group was 16.00%, the difference was statistically significant (P <0.05). Conclusion: High-dose atorvastatin can effectively improve the stability of atherosclerotic plaque and reduce the recurrence of cerebral infarction.