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目的探讨硫酸镁联合硝苯地平治疗妊娠高血压综合征患者的临床疗效。方法选取2014年1月至2015年10月于辽宁省营口市妇产儿童医院就诊的106例妊娠高血压综合征作为研究对象,按随机数字表法将其分为观察组与对照组,每组53例。对照组患者采用硫酸镁进行治疗,观察组患者在对照组治疗基础上给予硝苯地平控制片,比较两组患者治疗后24 h尿蛋白定量、血细胞压积、血黏度及临床疗效。结果治疗后,观察组患者24 h尿蛋白定量、血细胞压积、血黏度较均明显低于对照组,差异均有统计学意义(均P<0.05);观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论硫酸镁联合硝苯地平治疗妊娠期高血压综合,其疗效明显优于单纯使用硫酸镁,可有效改善患者临床症状,是改善预后、保障母婴安全的重要方法。
Objective To investigate the clinical efficacy of magnesium sulfate combined with nifedipine in the treatment of patients with pregnancy induced hypertension. Methods One hundred and sixty patients with pregnancy-induced hypertension (Hypertension syndrome) treated at Yingkou Maternity and Children’s Hospital in Liaoning Province from January 2014 to October 2015 were selected as study objects. According to the random number table, they were divided into observation group and control group, and each group 53 cases. Patients in the control group were treated with magnesium sulfate. Patients in the observation group were given nifedipine tablets on the basis of the control group. Urine protein, hematocrit, blood viscosity and clinical efficacy at 24 hours after treatment were compared between two groups. Results After treatment, 24 h urinary protein excretion, hematocrit and blood viscosity in the observation group were significantly lower than those in the control group (all P <0.05), and the total effective rate in the observation group was significantly higher In the control group, the difference was statistically significant (P <0.05). Conclusion Magnesium sulfate combined with nifedipine in the treatment of pregnancy-induced hypertension is superior to simple use of magnesium sulfate, which can effectively improve clinical symptoms. It is an important method to improve prognosis and ensure the safety of mother and infant.