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[目的]观察益肾汤联合贝那普利治疗早期糖尿病肾病疗效。[方法]使用随机平行对照方法,将97例住院患者按抛硬币法简单随机分为三组。西药组(A组)30例贝那普利,15mg/次,1次/d。中药组(B组)31例益肾汤(黄芪50g,人参10g,川芎15g,水蛭9g,丹参20g,三七15g),1剂/d,水煎200m L,早晚口服。中西结合组(C组)36例贝那普利联合益肾汤。连续治疗14d为1疗程。观测临床症状、尿微量蛋白比肌酐值、血糖、糖化血红蛋白、不良反应。连续治疗3疗程,判定疗效。[结果]A组痊愈10例,有效9例,无效11例,总有效率63.33%。B组痊愈8例,有效10例,无效13例,总有效率58.06%。C组痊愈19例,有效14例,无效3例,总有效率91.67%。C组>A组>B组(P<0.05)。尿微量蛋白比肌酐值三组均有改善(P<0.05),C组改善优于A、B组(P<0.05)。[结论]益肾汤联合贝那普利治疗早期糖尿病肾病效果显著,无严重不良反应,值得推广。
[Objective] To observe the therapeutic effect of Yishen Decoction combined with benazepril on early diabetic nephropathy. [Methods] Using randomized parallel control method, 97 inpatients were randomly divided into three groups according to the coin-tossing method. Western medicine group (group A) 30 benazepril, 15mg / time, 1 time / d. 31 cases of Yishen Decoction (Astragalus 50g, ginseng 10g, Chuanxiong 15g, leeches 9g, Salvia 20g, Panax notoginseng 15g) of Chinese medicine group (B group), 1 dose / d, decoction 200m L, oral and sooner or later. Chinese and Western combination group (C group) 36 benazepril combined with kidney soup. Continuous treatment 14d for a course of treatment. Clinical symptoms, urinary microalbuminuria, creatinine, blood glucose, glycosylated hemoglobin, and adverse reactions were observed. Continuous treatment of 3 courses to determine the efficacy. [Result] In group A, 10 cases were cured, 9 cases were effective and 11 cases were ineffective. The total effective rate was 63.33%. B group recovered in 8 cases, effective in 10 cases, ineffective in 13 cases, the total effective rate was 58.06%. In group C, 19 cases were cured, 14 cases were effective, 3 cases were ineffective, and the total effective rate was 91.67%. Group C> Group A> Group B (P <0.05). Urinary micro-protein than creatinine values were improved in three groups (P <0.05), C group improved better than A, B group (P <0.05). [Conclusion] Yishen Decoction combined with benazepril treatment of early diabetic nephropathy effect is significant, no serious adverse reactions, it is worth promoting.