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一、放射疗法的现状和进展视网膜母细胞瘤保存眼球的治疗方法最早是1903年美国的Hilgartner发表的X线外部照射。现在又采用了光凝、冷冻凝固和HPD光化学疗法。但是这些疗法只对直径在5mm以下的小肿瘤有效,并且对肿瘤周围的正常视网膜可产生不可逆的损害,对玻璃体内有转移的病例根本无效。目前,放射疗法存在的问题是放射性白内障,肿瘤复发率为40％,一旦复发再行照射,则发生放射性视网膜病变和放射性青光眼,有很高的失明率。为了解决这些问题,曾试用过很多方法。
First, the status and progress of radiation therapy Retinoblastoma preservation of the eyeball treatment method was first published in the United States in 1903 Hilgartner X-ray external exposure. Photocoagulation, cryocoagulation, and HPD photochemotherapy are now used. However, these therapies are effective only for small tumors below 5 mm in diameter and can cause irreversible damage to the normal retina around the tumor and are essentially ineffective in cases of metastases in the vitreous. At present, radiation therapy has a problem of radioactive cataracts, with a tumor recurrence rate of 40%. Once recurrence occurs, radiation retinopathy and radioactive glaucoma occur, resulting in high blindness rates. In order to solve these problems, many methods have been tried.