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目的:采用Meta分析方法系统评价乙型肝炎病毒(hepatitis B virus,HBV)感染与非霍奇金淋巴瘤(non-Hodgkinlymphoma,NHL)发病风险的相关性。方法:计算机检索Medline、EMBASE、PubMed、Cochrane图书馆、中国生物医学文献数据库、中国期刊全文数据库、中国科技期刊全文数据库,收集有关HBV感染与NHL发病风险相关性的病例对照研究。两名评价者独立提取纳入研究的有效信息,并使用STATA 11.0进行Meta分析。结果:共纳入15篇病例对照研究及8篇巢式病例对照研究文献。Meta分析结果显示,固定效应模型下比值比(odd radio,OR)为2.44(95%CI,2.25～2.63),随机效应模型下OR为2.49(95%CI,1.95～3.18),然而,所有的纳入研究间存在异质性(I2=86.8%,P<0.05)。亚组分析中纳入的巢式病例对照研究之间无异质性(I2=15.9%,P>0.05),随机效应模型下OR为2.16(95%CI,1.82～2.56),提示NHL患者HBV的感染率高于对照人群。结论:HBV感染可能增加NHL的发病风险,但仍需大量的实验及流行病学研究验证。
Objective: To evaluate the relationship between hepatitis B virus (HBV) infection and the risk of non-Hodgkinlymphoma (NHL) by Meta-analysis. Methods: A case-control study was conducted by computer searching Medline, EMBASE, PubMed, Cochrane Library, China Biomedical Literature Database, Chinese Journal Full-text Database, and Chinese Science and Technology Journals Full-text Database to collect data on HBV infection and NHL risk. Two reviewers independently extracted valid information for inclusion in the study and performed a meta-analysis using STATA 11.0. Results: A total of 15 case-control studies and 8 nested case-control studies were included. Meta-analysis showed that odds ratio (OR) was 2.44 (95% CI, 2.25-2.63) in the fixed effects model and 2.49 (95% CI, 1.95-3.18) in the random effects model. However, all There was heterogeneity among studies (I2 = 86.8%, P <0.05). There was no heterogeneity between the nested case-control studies included in the subgroup analysis (I2 = 15.9%, P> 0.05), and the odds ratio was 2.16 (95% CI, 1.82-2.56) in the random-effects model, Infection rate is higher than the control population. Conclusion: HBV infection may increase the risk of NHL, but still need a large number of experimental and epidemiological studies to verify.