论文部分内容阅读
杂交犬１４只，采用门静脉插管法，门脉内反复注射聚乙烯醇（ＰＶＡ），３个月后制成肝纤维化门脉高压症动物模型，出现脾大、腹水、食管静脉曲张等表现，门静脉造影显示门一体侧枝循环大量形成，病理检查显示肝细胞变性、坏死，肝纤维化形成。实验前后，分别测定门静脉压为９４．５±９．１ｍｍＨ２Ｏ（０．９３±０．０９ｋｐａ）和３０５．８±５７．９ｍｍＨ２Ｏ（３．００±０．５７ｋｐａ）（Ｘ±ｓ，ｎ＝１０，提示门脉高压症形成后，门脉压力明显升高（Ｐ＜０．００１）。结果与肝硬化门脉高压症临床表现相一致。为进一步研究肝内型门脉高压症发病机制提供了极为理想的动物模型。
Fourteen dogs were randomly divided into three groups: portal vein catheterization, repeated injection of polyvinyl alcohol (PVA) in the portal vein and animal model of portal hypertension after three months. Splenomegaly, ascites and esophageal varices appeared , Portal vein angiography showed a large number of collateral circulation formation, pathological examination showed that liver cell degeneration, necrosis, liver fibrosis. Before and after the experiment, the portal venous pressure was measured as 94.5 ± 9.1mmH2O (0.93 ± 0.09kpa) and 305.8 ± 57.9mmH2O (3.00 ± 0.57kpa) (X ± s, n = 10, (P <0.001) .The results are consistent with the clinical manifestations of cirrhosis and portal hypertension.To further study the pathogenesis of intrahepatic portal hypertension provides a very Ideal animal model.