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目的:比较雷公藤多苷与硫唑嘌呤片用于维持治疗狼疮性肾炎患者的临床疗效。方法:选取2013年9月—2015年11月期间收治的狼疮性肾炎患者55例作为研究对象,将其分为对照组(n=27)和观察组(n=28);对照组患者均给予硫唑嘌呤片治疗;观察组患者均给予雷公藤多苷片治疗;比较两组患者治疗后血红蛋白、血尿素氮、血清肌酐、补体C_3、补体C_4、24 h尿蛋白定量和不良反应的发生率及总有效率等。结果:两组患者治疗后的血红蛋白、血尿素氮、血清肌酐、补体C_3、补体C_4、24 h尿蛋白定量和不良反应的发生率等指标经比较其差异无统计学意义(P>0.05);两组患者治疗后的总有效率经比较其差异无统计学意义(P>0.05)。结论:采用雷公藤多苷片与硫唑嘌呤片治疗狼疮性肾炎患者的疗效和药物不良反应的发生率基本一致,临床使用时可针对患者的体质选用不同药物治疗。
OBJECTIVE: To compare the clinical efficacy of tripterygium glycosides and azathioprine tablets in the maintenance of patients with lupus nephritis. Methods: Fifty-five patients with lupus nephritis admitted from September 2013 to November 2015 were selected as control group (n = 27) and observation group (n = 28). Patients in control group were given The patients in the observation group were treated with Tripterygium glycosides tablets. The incidences of quantitative and adverse reactions of urinary protein in hemoglobin, blood urea nitrogen, serum creatinine, complement C_3, complement C_4, 24 h after treatment were compared between the two groups And total efficiency and so on. Results: There was no significant difference in the quantitative and adverse reactions of hemoglobin, blood urea nitrogen, serum creatinine, complement C_3, complement C_4, 24 h urine protein between the two groups after treatment (P> 0.05). After treatment, the total effective rate of the two groups was no significant difference (P> 0.05). Conclusion: The incidence of adverse reactions and adverse drug reactions in patients with lupus nephritis treated with tripterygium glycosides tablets and azathioprine tablets are basically the same. In clinical use, different drugs may be selected according to patients’ physique.