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[目的]探讨MED辅助下经椎间孔入路植骨融合(MED-TLIF)联合经皮椎弓根钉棒内固定治疗腰椎滑脱症的临床效果.[方法]回顾性分析2012年5月～ 2014年9月本院微创脊柱外科就诊的72例腰椎滑脱症患者,按时间前后随机分为A组37例(2012年5月～ 2013年5月)和B组35例(2013年6月～2014年9月),采用MED辅助下经椎间孔入路植骨融合(MED-TLIF)联合经皮椎弓根钉棒内固定治疗.[结果]两组所有患者均顺利完成手术,均获随访,时间22～ 26个月.A组JOA评分术前(17.8±1.3)分,术后(25.7±1.2)分,末次随访时(27.5±1.4)分,差异有统计学意义(P＜ 0.05).末次随访时滑移程度为3.7％±1.8％,滑脱复位率为89.5％,融合率为95.9％.B组JOA评分术前(17.3±1.5)分,术后(24.9±1.4)分,末次随访时(27.4±1.6)分,差异有统计学意义(P＜0.05).末次随访时滑移4.1％±1.7％,滑脱复位率为92.5％,融合率为96.2％.两组之间JOA评分、滑脱复位率、融合率差异无统计学意义(P＞0.05).[结论] MED辅助下经椎间孔入路植骨融合联合经皮椎弓根钉内固定治疗腰椎滑脱症具有创伤小、并发症少等优点,临床效果满意.“,”[Objective] To investigate the clinical outcome of MED-assisted transforaminal lumbar interbody fusion (MED-TLIF) combined with percutaneous pedicle screw fixation in the treatment of lumbar spondyloli sthesis.[Methods] Seventy-two patients with lumbar spondylolisthesis were treated with MED-TLIF from May 2012 to September 2014.According to the time of operation,patients were divided into group A (n=37 cases,May 2012 ～ May 2013) and group B (n=35 cases,June 2013 ～ September 2014).The JOA score,reduction rate of spondylolisthesis,as well as final fusion rate were recorded and compared between two groups.[Results] All patients successfully completed surgery and were followed up for 22 to 26 months.The JOA score in group A were (17.8 + 1.3),(25.7 ± 1.2),(25.7 ±1.4) before,after operation and at the end of the follow-up,showing statistically significant differences (P ＜ 0.05).At the last follow-up,the degree of slippage was 3.7％ + 1.8％,with the total reduction rate of 89.5％,and the fusion rate of 95.9％.The JOA score in group B were (17.3± 1.5),(24.9 ± 1.4),(27.4 ± 1.6) before,after operation and at the end of the follow-up,also showing statistically significant differences (P ＜ 0.05).At the last follow-up,the degree of slippage was 4.1％ + 1.7％,with the total reduction rate of 92.5％,and the fusion rate of 96.2％.Statistical analysis indicated that,there was no significant differences in the JOA score,the reduction rate and the fusion rate between the two groups (P＞0.05).[Conclusion] For treatment of lumbar spondylolisthesis,MED-TLIF has advantages of less trauma,less complications,and satisfactory clinical coutcome.