四氯化碳是良好的有机溶剂 ,但毒性大 ,自 19世纪 2 0年代即被认为是肝毒物质 [1]。过去几十年来对它的肝毒性作了大量研究 ,先后提出了不少学说 ,其中主要有肝细胞代谢障碍学说 [2 ]、交感神经紊乱学说 [3]、肾上腺髓质应急学说 [4]、自由基学说 [5 ]。为综合观察四氯化碳对肝 Carbon tetrachloride is a good organic solvent, but its toxicity is so great that it has been considered a hepatotoxic material since the 1920s [1]. There have been many studies on its hepatotoxicity in the past few decades and many theories have been put forward. Among them are the theory of hepatocyte metabolic disorder [2], the theory of sympathetic disorders [3], the emergency theory of adrenal medulla [4], Free radical theory [5]. For a comprehensive observation of carbon tetrachloride on the liver