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目的探讨乳杆菌活菌胶囊、干扰素α-2b栓联合宫颈环形电切术(LEEP)治疗宫颈上皮内瘤变(CIN)伴高危型人乳头瘤病毒感染(HR-HPV)的疗效。方法选取84例就诊的CIN伴HR-HPV感染患者随机分为观察组和对照组。两组于月经后5~7d行LEEP术,观察组于LEEP术后3d予以乳杆菌活菌胶囊[阴道放置,每次1粒(0.25g),每晚1次]联合干扰素α-2b栓[阴道内放置,每晚1枚(10万IU),隔日1次]治疗;对照组予以单用的干扰素α-2b栓治疗,两组连用3个月经周期。两组术后观察其阴道出血量、创面愈合时间、阴道流液时间及并发症,术后6个月比较CIN治疗效果及HRHPV清除率。结果观察组术后阴道出血量、创面愈合时间及阴道流液时间均少于或短于对照组(P<0.05)。观察组和对照组术后分别出现并发症2例和8例,观察组术后并发症发生率低于对照组(χ~2=4.09,P<0.05)。术后6个月,观察组CIN病变治愈率高于对照组,CIN病变持续或残存率低于对照组(χ~2=3.98,P<0.05),HR-HPV清除率明显高于对照组(χ~2=5.13,P<0.05)。结论乳杆菌活菌胶囊、干扰素α-2b栓联合LEEP术治疗CIN伴HR-HPV感染可促进术后创面的愈合,减少阴道出血量,缩短阴道流液时间,减少术后并发症;并可提高CIN病变治愈率,更有效清除HR-HPV感染。
Objective To investigate the efficacy of Lactobacillus live capsule and interferon α-2b suppository combined with cervical ring electrotomy (LEEP) in the treatment of cervical intraepithelial neoplasia (CIN) with high-risk human papillomavirus (HR-HPV). Methods 84 cases of CIN with HR-HPV infection were randomly divided into observation group and control group. LEEP was performed 5 to 7 days after menstruation in both groups, and the observation group was treated with Lactobacillus live capsule [1g (0.25g each time, once a night]) after LEEP. The interferon α-2b [Placed intravaginally, one night (100,000 IU) every other day], and the control group was treated with interferon alfa-2b alone. The two groups were given three menstrual cycles. Two groups were observed postoperative vaginal bleeding, wound healing time, vaginal fluid time and complications, 6 months after CIN treatment and HRHPV clearance rate. Results The volume of postoperative vaginal bleeding, wound healing time and vaginal fluid time in the observation group were both shorter than those in the control group (P <0.05). Two cases and 8 cases of complications occurred in the observation group and the control group, respectively. The incidence of postoperative complications in the observation group was lower than that in the control group (χ ~ 2 = 4.09, P <0.05). At 6 months after operation, the cure rate of CIN in the observation group was higher than that of the control group, and the persistent or residual rate of CIN lesion was lower than that of the control group (χ ~ 2 = 3.98, P <0.05). HR-HPV clearance rate was significantly higher than that of the control group χ ~ 2 = 5.13, P <0.05). Conclusion Lactobacillus live capsule and interferon α-2b suppository combined with LEEP in the treatment of CIN with HR-HPV infection can promote wound healing, reduce the amount of vaginal bleeding, shorten the time of vaginal fluid flow and reduce postoperative complications. Improve the cure rate of CIN lesions, more effectively clear HR-HPV infection.