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目的探讨病毒性肝炎合并糖尿病对乙肝疫苗免疫接种效果的影响及对策分析。方法选取3个免疫接种中心的50例肝炎合并糖尿病患者,为观察组;随机选取50例健康受试者,为对照组。两组成员均按标准接种程序完成乙肝疫苗接种,并于接种后1、6个月,检测抗HBs的转阳率以及抗体滴度。结果在接种后1、6个月的检测结果显示:观察组的抗HBs的转阳率小于对照组(P<0.05),平均抗体滴度小于对照组(P<0.05);在全程接种1、6个月后对观察组中低/无应答者进行复种1次,2个月复检时,抗HBs的转阳率以及抗体滴度有显著提高。结论合并糖尿病降低了乙肝疫苗免疫接种效果,在复种后能够提高乙肝疫苗免疫接种成功率。
Objective To investigate the effect of hepatitis B vaccine immunization on viral hepatitis with diabetes mellitus and its countermeasures. Methods Fifty patients with hepatitis with diabetes mellitus in three immunization centers were selected as the observation group. Fifty healthy subjects were randomly selected as the control group. Both groups completed hepatitis B vaccination according to the standard inoculation procedure and tested the anti-HBs positive rate and antibody titer at 1,6 months after inoculation. Results The test results at 1 and 6 months after inoculation showed that the positive rate of anti-HBs in observation group was lower than that in control group (P <0.05), and the average antibody titer was lower than that in control group (P <0.05) After 6 months in the observation group of low / non-responders were doubled 1, 2 months retest, anti-HBs positive rate of positive and antibody titers increased significantly. Conclusion Combined diabetes mellitus can reduce the effect of hepatitis B vaccine immunization and improve the success rate of hepatitis B vaccine immunization.