研制溶剂 -非溶剂法制备诺氟沙星微囊以乙基纤维素为囊材的最适溶剂 -非溶剂系统的组成 .采用 4种不同的溶剂 -非溶剂系统用同一工艺条件制备 ,计算包囊率和收率 ,转篮法测定释药特性 .二氯甲烷 -正己烷对于制备诺氟沙星微囊较适宜 ,包囊率在 4种溶剂 -非溶剂系统中最高达 90 .90 % ,收率为 87.2 7% ,且缓释作用最好 .该系统有机溶剂沸点较低 ,利于除去微囊产品中的有机溶剂 ,减少对机体的毒性 .以二氯甲烷 -正己烷为溶剂 -非溶剂制备诺氟沙星微囊包囊率大 ,收率高 ,适于工业化生产 Preparation of solvent-non-solvent method Norfloxacin microcapsules with ethylcellulose as the most suitable solvent - non-solvent system of the composition of the system using four different solvent - non-solvent system with the same process conditions, calculate the package The rate and the yield of spinosad were determined.The spinach method was used to determine the drug release characteristics.Dichloromethane-n-hexane was more suitable for the preparation of norfloxacin microcapsules.The encapsulation rate was up to 90.90% in four solvent-nonsolvent systems, The yield was 87.2 7%, and the slow release was the best.The low boiling point of the organic solvent in the system is conducive to the removal of organic solvents in the microcapsule products to reduce the toxicity to the body with methylene chloride - n-hexane as solvent - non-solvent Preparation of norfloxacin microcapsules cysts rate, high yield, suitable for industrial production