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目的 :了解吗丁啉促进胆囊排空的疗效。方法 :超声对比观察 2 6例慢性肝病患者及 2 2例正常对照者空腹胆囊大小及脂肪餐后胆囊收缩情况。 2 0例有胆囊排空障碍的患者 ,给予吗丁啉 ,每次 10 m g,3次 /d,治疗 4周后复查。结果 :正常对照组与慢性肝病组餐前胆囊面积及餐后胆囊收缩率差异均有非常显著性意义 (均 P <0 .0 1)。慢性肝炎组存在餐后胆囊排空障碍。2 0例有排空障碍的慢性肝病患者经吗丁啉治疗 4周后 ,胆囊排空有显著改善。结论 :慢性肝病患者常伴有胆囊排空运动障碍 ,吗丁啉有改善胆囊排空障碍的作用
Objective: To understand the efficacy of domperidone to promote gallbladder emptying. Methods: Fasting gallbladder size and postprandial cholecystolithiasis were observed in 26 patients with chronic liver disease and 22 normal controls by ultrasound contrast. Twenty patients with a history of gallbladder emptying were treated with domperidone 10 mg once daily for 4 weeks. Results: There was a significant difference between preoperative gallbladder area and postprandial gallbladder shrinkage in normal control group and chronic liver disease group (all P <0.01). Chronic hepatitis group had postprandial gallbladder emptying disorder. Gallbladder emptying was significantly improved after 20 weeks of morphine treatment in 20 patients with chronic liver disease with emptying disorder. Conclusion: Patients with chronic liver disease often accompanied by gallbladder emptying dyskinesia, domperidone can improve the role of gallbladder emptying disorders