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本文对近 6年来我室行遗传咨询的 32 0对妊娠胎儿丢失夫妇进行细胞遗传学分析 ,发现染色体异常 2 1例 ,占被检夫妇的 3 2 8% ,其中男性 8例 ,女性 13例 ;易位核型 11例 ,占异常核型总数的 5 2 4% ,其中 2例为世界首报核型 :t(12 ;15 )、t(2 ;3)。 9号染色体臂间倒位 7例 ,占 33 3%。结果阐明了染色体异常是妊娠胎儿丢失的重要遗传因素 ,对指导优生与提高人口素质具有重要的意义。
This article analyzes the cytogenetic analysis of 32 couples who lost their gestation fetuses during the past 6 years and found 21 cases of chromosomal abnormalities, accounting for 32.8% of the tested couples, including 8 males and 13 females. Translocation karyotype in 11 cases, accounting for 52.4% of the total number of abnormal karyotype, of which two cases of the world’s first report of karyotype: t (12; 15), t (2; 3). There were 7 cases of inversions on chromosome 9, accounting for 33.3%. The results clarify the chromosomal abnormalities is an important genetic factor in fetal loss of pregnancy, the guidance of eugenics and improve the quality of the population is of great significance.