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为研究进行性慢性肾功能衰竭(CRF)患者不同病期的出血情况及其出血机理,作者测定了31例泌尿系疾患引起的CRF患者的出血时间和血小板功能,并与22例健康者进行对照比较,依血肌酐(Cr)值将患者分为轻度(Cr120-300μmol/l,共10例)、中度(Cr300-600μmol/l,共14例)和重度(Cr>600μmol/l,共7例)CRF。测定的项目包括出血时间,血小板聚集率(诱导剂为ADP,胶原和瑞斯托霉素)、自发性聚集率、血栓烷(TXB_2)、血浆纤维蛋白原,von Willebrand因子(vWF)及C-反应蛋白(CRP)等。结果:大多数CRF患者的出血时间在正常范围内。因有1例轻度CRF患
To investigate the bleeding and bleeding at different stages of patients with progressive chronic renal failure (CRF), we measured the bleeding time and platelet function in 31 CRF patients with urological disorders and compared them with 22 healthy controls The patients were divided into mild (Cr120-300μmol / l, 10 cases), moderate (Cr300-600μmol / l, 14 cases) and severe (Cr> 600μmol / 7 cases) CRF. Measured items included bleeding time, platelet aggregation rate (inducer of ADP, collagen and ristocetin), spontaneous aggregation rate, thromboxane (TXB_2), plasma fibrinogen, von Willebrand factor (vWF) and C- Reactive protein (CRP) and so on. Results: Most patients with CRF had bleeding within the normal range. Because of a mild CRF patients