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目的 :观察狼性肾炎 (SLE)肾小管间质病变与临床生化指标的关系。方法 :46例狼疮性肾炎患者行肾活检 ,按小管间质损害程度积分 :轻度损害≤ 2分 ,中度 3～ 5分、重度≥ 6例 ,同时测定每例患者肌酐清除率(Ccr)、2 4h尿蛋白定量、尿 β2 -微球蛋白 (β2 -MG)、尿Tamm -Horsfall蛋白 (THP)及尿渗透压。结果 :肾间质损害程度与肌酐清除率、尿渗透压成正比 ,与尿蛋白成反比。结论 :狼疮性肾炎肾间质病变具有重要的临床意义。测定某些临床指标可判断肾间质损害程度
Objective: To observe the relationship between tubulointerstitial lesions of wolf nephritis (SLE) and clinical and biochemical indexes. Methods: 46 patients with lupus nephritis underwent renal biopsy, according to the degree of tubulointerstitial damage integral: mild damage ≤ 2 points, moderate 3 to 5 points, severe ≥ 6 cases, and determination of each patient creatinine clearance rate (Ccr) , 24 h proteinuria, β2 - microglobulin (β2 - MG), urine Tamm - Horsfall protein (THP) and urine osmotic pressure. Results: The degree of renal interstitum damage was directly proportional to creatinine clearance and urine osmolality, and inversely with urine protein. Conclusion: The lupus nephritis renal interstitial lesions have important clinical significance. Determination of certain clinical indicators can determine the extent of renal interstitial damage