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目的探讨复治性非小细胞肺癌的治疗方法。方法对62例放化疗后未控制病情的非小细胞肺癌患者进行氩氦刀冷冻联合介入治疗,测定治疗前后血清肿瘤标志物(NSE、CEA、CY21-1)含量及细胞核仁组成区相关蛋白(Ag-NORs)值(I.S%、I.O.D%),观察其疗效及1年生存率。结果治疗后血清标志物测定明显降低,(P<0.01);I.S%、I.O.D%值明显降低,(P<0.05);有效率79.0%(49/62),1年生存率80.6%(50/62)。结论氩氦刀联合介入对复治性非小细胞肺癌仍然有效。是解决复发难治性非小细胞肺癌的新途径。
Objective To investigate the treatment of retreatment non-small cell lung cancer. Methods Sixty-two patients with non-small cell lung cancer after radiotherapy and chemotherapy were treated with argon helium cryoablation and interventional therapy. The serum tumor markers (NSE, CEA, CY21-1) and related proteins of nucleolar organizer were determined before and after treatment. Ag-NORs values (IS%, IOD%) were observed for efficacy and 1-year survival. Results Serum markers were significantly lower after treatment (P<0.01); IS% and IOD% were significantly lower (P<0.05); Effectiveness was 79.0% (49/62); 1-year survival was 80.6% (50/ 62). Conclusion Argon-helium combined intervention is still effective for retreatment of non-small cell lung cancer. It is a new way to solve relapsed and refractory non-small cell lung cancer.