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[目的]探讨地西泮和乙醇合用引起中枢抑制导致中毒的两者量的关系。[方法]制做乙醇灌胃组、地西泮注射组、地西泮合用低剂量乙醇组以及地西泮合用高剂量乙醇组小鼠动物模型,观察记录30min内小鼠的翻正反射消失的阳性率及小鼠的应激反应。[结果]量效曲线随着乙醇浓度增加而向左向上偏移。[结论]地西泮合用乙醇时,两者显示出协同效应。
[Objective] To investigate the relationship between the amount of diazepam and ethanol caused by central inhibition caused by poisoning. [Method] The animal models of ethanol-gavage group, diazepam injection group, diazepam combined with low-dose ethanol group and diazepam combined with high-dose ethanol group were made to observe the disappearance of the normal reflex of the mice in 30 min Positive rate and stress response in mice. [Result] The dose-response curve shifted to the left upward with the increase of ethanol concentration. [Conclusion] Synergistic effect was observed when diazepam was combined with ethanol.