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目的：探讨沙美特罗替卡松联合噻托溴铵粉吸入剂治疗慢性阻塞性肺疾病（COPD）的临床效果。方法：选择 COPD 的患者90例，随机分为观察组和对照组各45例。观察组给予沙美特罗替卡松联合噻托溴铵粉吸入剂治疗；对照组给予单纯沙美特罗替卡松治疗。观察两组患者治疗前后的呼吸困难评分、血气及肺功能情况。结果：观察组呼吸困难的下降值显著高于对照组（P ＜0．01），观察组的肺功能指标（FVC、FEV，及 FEV mvc％）及血气指标（SaO2、PaO2）明显增高，而 PaCO2则显著下降，两者比较差异有非常显著性差异（p ＜O．01）。结论：沙美特罗替卡松联合噻托溴铵治疗 COPD 效果满意，优于单纯沙美特罗替卡松治疗 COPD，值得借鉴。“,”Objective:To investigate the Shah Met e Lo fluticasone combined with Tiotropium Bromide Powder for Inhalation in treatment of chronicobstructive pulmonary disease (COPD)clinical ef ect.Methods:90 cases ofCOPD patients,were randomly divided into observation group and controlgroup with 45 cases in each group.Results:the observation groupde-creased respiratory dif iculty value was significantly higher than that of control group ((P <0.01),lung function indexes of the observation group(FVC,FEV,and FEV mvc%)and blood gas parameters (SaO2,PaO2)were significantly increased,while PaCO2 decreased significantly,there was significant dif erence in dif erence between the two groups ((P <0.01).Conclusion:Shah Met e Lo and fluticasone propionate combined tiotropiumCOPD satisfactory results,bet er than simple Shah Met e Lo Tikason in the treatment of COPD,and is worthy of reference.