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恶性肿瘤是威胁人类健康、危及生命的重大疾病之一。在一些发达国家,肿瘤引起的死亡已占死因的第一位,并因此投入了大量的人力和物力,开展肿瘤治疗药物的研究与开发。多年来,我国的肿瘤治疗药物研究一直是国家的重点药物研究项目之一。研究者不断寻找新的抗肿瘤物质,希望发现特异性较好,抗肿瘤活性强,有新作用机制以及对抗药性肿瘤有效的药物,其中烯二炔类化合物是非常有特色、很有发展前景的新型抗癌药物。
Malignancy is one of the major diseases that threaten human health and endanger life. In some developed countries, the death caused by cancer has taken the first place in the cause of death, and therefore invested a lot of manpower and material resources to carry out research and development of cancer treatment drugs. Over the years, China’s cancer drug treatment research has been one of the country’s key drug research projects. Researchers are constantly searching for new anti-tumor substances, hoping to find drugs with good specificity, strong anti-tumor activity, new mechanism of action and effective against drug-resistant tumors. Among them, the enediyne compounds are very unique and promising New anti-cancer drugs.