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本实验室最新的研究资料表明,中枢内cAMP的生成受限可能是致热原性发热时热限的重要成因之一。本研究结果显示:(1)在一定范围内,家兔侧脑室注射Db-cAMP(Dibutyryl cyclic AMP,双丁酰环腺苷—磷酸)可以引起依赖于剂量的发热效应,而大剂量时可出现cAMP热限;(2)非热限剂量Db-cAMP加非热限剂量EP(endogenous pyrogen,内生致热原)负荷,表现出两者致热效应的叠加;(3)Db-cAMP热限加热剂量EP负荷,发热高度没有突破EP热限或Db-cAMP热限水平;Db-cAMF热限加热限剂量ET(endotxin,内毒素)负荷,发热高度接近ET热限,但明显高于Db-cAMP热限水平。作者推论,cAMP热限的产生可能与中枢内cAMP的作用点达到饱和有关。在EP热限或ET热限的成因中,既有中枢内cAMP生成受限,又可能同时有中枢内cAMP作用点达到饱和、或cAMP后继介质生成受限。ET热限的构成,除cAMP以外,同时可能还有其它因素参与。
The latest research data in our laboratory shows that the limited production of cAMP in the central nervous system may be one of the important causes of pyretic fever. The results of this study showed that: (1) Db-cAMP (Dibutyryl cyclic AMP) can induce dose-dependent febrile effects in a certain range in rabbits, but cAMP may occur at high dose (2) Db-cAMP plus endogenous pyrogen (EP) load, showing a superposition of pyrogenic effects; (3) Db-cAMP heat-limited heating dose EP Db-cAMF heat load limit ET (endotxin, endotoxin) load, fever highly close to the ET heat limit, but significantly higher than the Db-cAMP heat limit Level. The authors conclude that the generation of cAMP heat-limiting may be related to the saturation of cAMP in the central nervous system. In the causes of EP heat limit or ET heat limit, both central cAMP generation is limited, but also may have the central role of cAMP saturation point, or cAMP subsequent media generation is limited. ET heat limit composition, in addition to cAMP at the same time there may be other factors involved.