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目的:比较术前使用与术后使用生长抑素与对减轻腹腔镜胃癌根治术所致胰腺损伤的疗效差异。方法:50例拟行腹腔镜胃癌根治术的患者随机均分为观察组(术前12~24 h开始使用生长抑素,术中及术后维持)或对照组(术后使用生长抑素),5例患者中途退出研究,最终观察组纳入22例,对照组23例。比较两组相关临床指标。结果:两组一般资料及术前感染、营养指标差异均无统计学意义(均P>0.05)。与对照组比较,观察组术后第1天腹腔引流量明显低于对照组(P=0.016),但术后总引流量两组无明统计学差异(P>0.05);两组间围手术期血清淀粉酶浓度、腹腔引流液淀粉酶含量、术后感染与营养指标、引流管拔除时间、胃肠动力恢复与并发症情况均无统计学差异(均P>0.05)。结论:术前、术后使用生长抑素比较,在减轻腹腔镜胃癌根治术所致胰腺损伤方面无明显差异。
OBJECTIVE: To compare the efficacy of preoperative and postoperative use of somatostatin and to reduce the pancreatic damage caused by laparoscopic radical gastrectomy. Methods: Fifty patients undergoing laparoscopic radical gastrectomy were randomly divided into observation group (somatostatin was started at 12-24 hrs before surgery, intraoperative and postoperative maintenance) or control group (postoperative use of somatostatin) , 5 patients withdraw from the study halfway, the final observation group included 22 cases, control group 23 cases. Compare the two groups of related clinical indicators. Results: The two groups of general information and preoperative infection, nutritional indicators were no significant difference (all P> 0.05). Compared with the control group, the drainage volume of the abdominal cavity on the first postoperative day in the observation group was significantly lower than that of the control group (P = 0.016), but there was no significant difference between the two groups (P> 0.05) There was no significant difference in serum amylase concentration, amylase content in peritoneal drainage, postoperative infection and nutritional index, drainage tube drainage time, gastrointestinal motility recovery and complications (all P> 0.05). Conclusion: Compared with somatostatin before and after operation, there is no significant difference in reducing pancreatic injury due to laparoscopic radical gastrectomy.