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采用 EL ISA方法检测 2 2例肝硬化及 110例乙型肝炎患者血清肿瘤坏死因子 (TNF)含量。结果显示 :肝硬化病人血清 TNF水平最高 ;乙肝慢性迁延型、急性乙肝、乙肝慢性活动性、急性重症乙肝和慢性重症乙肝血清 TNF水平则依次升高 ,与对照组比较均有显著性差异 (P<0 .0 1) ,并发现肝硬化和慢性重症乙肝合并腹腔感染者血清TNF水平也显著高于未合并感染者 (P<0 .0 1)。结果揭示血清 TNF水平与肝硬化和乙肝类型密切相关 ,血清 TNF水平对肝硬化和乙肝类型的诊断、疗效判断均具有一定参考价值。
The levels of serum tumor necrosis factor (TNF) in 22 patients with cirrhosis and 110 patients with hepatitis B were detected by ELISA. The results showed that the level of serum TNF in patients with cirrhosis was the highest. Chronic persistent hepatitis B, chronic hepatitis B, chronic active hepatitis B, acute severe hepatitis B and chronic severe hepatitis B serum TNF levels in turn increased, compared with the control group were significantly different (P <0.01), and found that serum TNF levels in patients with cirrhosis and chronic severe hepatitis B infection were significantly higher than those without infection (P <0.01). The results revealed that serum TNF levels are closely related to cirrhosis and hepatitis B type. Serum TNF level has certain reference value for the diagnosis and curative effect of cirrhosis and hepatitis B type.